Ivermectin

Name Avermectin EP6.0 The purity of B1 is not fless than 95% in dry product,B1a is at least 90%.

                                              AVERMECTIN

Name  Avermectin

(Origin) It is a liquid fermentation product of Streptomyces a vermitilis and is a mixture of Avermectin B1a and B1b

(Formula and Molecular Weight)  B1a C48H72O14=873.1

                               B1b C47H70O14=859.1

(Ingredient)The purity of B1 is not fless than 95% in dry product,B1a is at least 90%.

(Description)White or light yellow crystal. Melting point:157-162.C

Solubility: The product is easily soluble in toluene, ethyl acetate, acetone, chloroform, chloroform, ethanol and the like, slightly soluble in hexane and petroleum ether. Its-solubility in water is very low (10ug/L).

(Toxicity)  The oral LD50 value in mice:13.6-23.8mg/kg b.w.

             The oral LD50 value in rat:10.6-11.3mg/kg b.w.

            

(Use)1.the goods used in agriculture pesticides, efficient and low toxicity, broad-spectrum insecticide scope, the application of various plants, killing Plutella xylostella,Pieris rapea,leafminers,Ling-pest cotton,rice longitudinal leafroll Moth,psylla,mites,nematodes,etc..

2.Benpinwei antibiotics to nematodes, insects and mites are flooding and killed,Using this product made of injection, tables, mainly through penetration engenders in the treatment of gastrointestinal nematode livestock, hides myiasis, mosquito paper myiasis, sheep nose myiasis, sheep and pig itch mite, sheep scabies mite disease.

3. the synthesis of materials for pharmaceutical raw materials Ivermectin Emamectin benzoate.

                                     CERTIFICATE  OF  ANALYSIS

Product Name  Ivermectin	Specification   EP6
Quantity    150kg	Batch NO.     2010011701
Manuf.Date    2010.01.04	Exp.  Date    2012.01

ITEM	SPECIFICATION	RESULT
Characters Appearance   Solubility	White Or Yellowish-White Crystalline Powder Practically insoluble in water,freely soluble in methylene,chloride,soluble in alcohol.	Complies
Identificatio IRHPLC	Conform  Conform	Complies
Appearance Of  Solution	Solution Is Clear≤BY7	Complies
4.Specific Optical Rotation(°)	-17  — -20°	-19.2°
5.Related Substances (1.3<RRT<1.5)Indiv.Impurity(%) And other impurity(%)  Total impurity(%)	≤2.5%   ≤1.0%   ≤5.0%	1.8%   0.6%   3.5%
6.Ethanol (%) Formamide(%)	≤5.0% ≤3.0%	4.3% 2.5%
7. Heavy Metals(%)	≤0.002%	0.002%
8.Water(%)	≤1.0%	0.1%
9.Sulphated ash(%)	≤0.1%	0.1%
10.the content of H2B1(%) H2B1a/H2B1	95.0—102.0 ≥90.0%	96.0% 97.7%
Note:The item of 4 and 10 calculated on the anhydrous and solvent-free substance.
CONCLUSIONCOMPLIES  WITH  EP6.0

Ivermectin